@ShaneyWright > Anyone with experience of these in a #LongCovid context? Yes. I use Candesartan: it’s an AT1 antagonist. The linked article discusses Angiotensin II as driving ER stress—of note especially given recently documented link between ER stre
@ejustin46 Angiotensin II activates NLRP3. ACE2 is a key regulator of the renin-angiotensin system, responsible for cleavage of Angiotensin II. #Covid causes RAS activation with simultaneous #ACE2 downregulation, preventing Ang II degradation and resulti
RT @8Eevert: @UntoNuggan > Ang II induces NLRP3 inflammasome activation —https://t.co/OYV50mfbRy > NLRP3 inflammasome is crucial > for COV…
@UntoNuggan > Ang II induces NLRP3 inflammasome activation —https://t.co/OYV50mfbRy > NLRP3 inflammasome is crucial > for COVID-19 and Alzheimer’s disease —Angiotensin II Receptor Antagonist Candesartan as an NLRP3 Inflammasome Inhibitor. Front I