Title |
FAF-Drugs2: Free ADME/tox filtering tool to assist drug discovery and chemical biology projects
|
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Published in |
BMC Bioinformatics, September 2008
|
DOI | 10.1186/1471-2105-9-396 |
Pubmed ID | |
Authors |
David Lagorce, Olivier Sperandio, Hervé Galons, Maria A Miteva, Bruno O Villoutreix |
Abstract |
Drug discovery and chemical biology are exceedingly complex and demanding enterprises. In recent years there are been increasing awareness about the importance of predicting/optimizing the absorption, distribution, metabolism, excretion and toxicity (ADMET) properties of small chemical compounds along the search process rather than at the final stages. Fast methods for evaluating ADMET properties of small molecules often involve applying a set of simple empirical rules (educated guesses) and as such, compound collections' property profiling can be performed in silico. Clearly, these rules cannot assess the full complexity of the human body but can provide valuable information and assist decision-making. |
X Demographics
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Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 50% |
Singapore | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 3 | 1% |
United Kingdom | 3 | 1% |
Indonesia | 2 | <1% |
India | 2 | <1% |
Brazil | 2 | <1% |
Romania | 2 | <1% |
France | 1 | <1% |
Mexico | 1 | <1% |
Belgium | 1 | <1% |
Other | 2 | <1% |
Unknown | 237 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 51 | 20% |
Researcher | 46 | 18% |
Student > Master | 28 | 11% |
Student > Bachelor | 27 | 11% |
Student > Doctoral Student | 14 | 5% |
Other | 54 | 21% |
Unknown | 36 | 14% |
Readers by discipline | Count | As % |
---|---|---|
Chemistry | 62 | 24% |
Agricultural and Biological Sciences | 48 | 19% |
Biochemistry, Genetics and Molecular Biology | 36 | 14% |
Pharmacology, Toxicology and Pharmaceutical Science | 20 | 8% |
Medicine and Dentistry | 14 | 5% |
Other | 31 | 12% |
Unknown | 45 | 18% |