Prion diseases are a class of fatal neurodegenerative disorders that can be sporadic, genetic or iatrogenic. They are characterized by the unique nature of their etiologic agent: prions (PrP(Sc)). A prion is an infectious protein with the ability to convert the host-encoded cellular prion protein (PrP(C)) into new prion molecules by acting as a template. Since Stanley B. Prusiner proposed the "protein-only" hypothesis for the first time, considerable effort has been put into defining the role played by PrP(C) in neurons. However, its physiological function remains unclear. This review summarizes the major findings that support the involvement of PrP(C) in signal transduction.
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 March 2013.
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#20,657,128
of 25,374,917 outputs
Outputs from Cellular & Molecular Biology Letters
#304
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#160,944
of 208,572 outputs
Outputs of similar age from Cellular & Molecular Biology Letters
#4
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So far Altmetric has tracked 606 research outputs from this source. They receive a mean Attention Score of 2.8. This one is in the 23rd percentile – i.e., 23% of its peers scored the same or lower than it.
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