Title |
Molecular targets in urothelial cancer: detection, treatment, and animal models of bladder cancer
|
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Published in |
Drug Design, Development and Therapy, October 2016
|
DOI | 10.2147/dddt.s112113 |
Pubmed ID | |
Authors |
Dmitriy Smolensky, Kusum Rathore, Maria Cekanova |
Abstract |
Bladder cancer remains one of the most expensive cancers to treat in the United States due to the length of required treatment and degree of recurrence. In order to treat bladder cancer more effectively, targeted therapies are being investigated. In order to use targeted therapy in a patient, it is important to provide a genetic background of the patient. Recent advances in genome sequencing, as well as transcriptome analysis, have identified major pathway components altered in bladder cancer. The purpose of this review is to provide a broad background on bladder cancer, including its causes, diagnosis, stages, treatments, animal models, as well as signaling pathways in bladder cancer. The major focus is given to the PI3K/AKT pathway, p53/pRb signaling pathways, and the histone modification machinery. Because several promising immunological therapies are also emerging in the treatment of bladder cancer, focus is also given on general activation of the immune system for the treatment of bladder cancer. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 1 | 50% |
Members of the public | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 62 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 10 | 16% |
Researcher | 8 | 13% |
Student > Ph. D. Student | 6 | 10% |
Student > Master | 5 | 8% |
Student > Doctoral Student | 3 | 5% |
Other | 6 | 10% |
Unknown | 24 | 39% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 16 | 26% |
Medicine and Dentistry | 8 | 13% |
Agricultural and Biological Sciences | 4 | 6% |
Immunology and Microbiology | 3 | 5% |
Nursing and Health Professions | 1 | 2% |
Other | 5 | 8% |
Unknown | 25 | 40% |