Title |
Inflammation Shapes Stem Cells and Stemness during Infection and Beyond
|
---|---|
Published in |
Frontiers in Cell and Developmental Biology, November 2016
|
DOI | 10.3389/fcell.2016.00118 |
Pubmed ID | |
Authors |
Stella Michael, Charis Achilleos, Theofano Panayiotou, Katerina Strati |
Abstract |
The outcome of an inflammatory incident can hang in the balance between restoring health and tissue integrity on the one hand, and promoting aberrant tissue homeostasis and adverse outcomes on the other. Both microbial-related and sterile inflammation is a complex response characterized by a range of innate immune cell types, which produce and respond to cytokine mediators and other inflammatory signals. In turn, cells native to the tissue in question can sense these mediators and respond by migrating, proliferating and regenerating the tissue. In this review we will discuss how the specific outcomes of inflammatory incidents are affected by the direct regulation of stem cells and cellular plasticity. While less well appreciated than the effects of inflammatory signals on immune cells and other differentiated cells, the effects are crucial in understanding inflammation and appropriately managing therapeutic interventions. |
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Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 74 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 13 | 18% |
Researcher | 9 | 12% |
Student > Master | 7 | 9% |
Student > Bachelor | 6 | 8% |
Professor | 5 | 7% |
Other | 12 | 16% |
Unknown | 22 | 30% |
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Medicine and Dentistry | 11 | 15% |
Agricultural and Biological Sciences | 10 | 14% |
Neuroscience | 3 | 4% |
Immunology and Microbiology | 3 | 4% |
Other | 5 | 7% |
Unknown | 25 | 34% |