https://t.co/C3DbVCAaMT "As the O-GlcNAcylation homeostasis-TS axis mediates the response to 5-FU, we propose to combine an OGA inhibitor with 5-FU-based therapies to enhance CRC patient response to 5-FU."
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3,858 followers
https://t.co/C3DbVCAaMT Together, these data indicate that, in a cancer type-dependent manner, activation or inhibition of O-GlcNAcylation in combination with BTZ proteasome inhibitor is a promising clinical strategy against resistance to therapy."
3,858 followers
https://t.co/C3DbVCAaMT "The use of pharmacological inhibitors of OGT (alloxan) and OGA (PUGNAc, Thiamet-G, ketoconazole (KCZ)) respectively abrogate and sensitize to BTZ-induced apoptosis in MCL cell lines."
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https://t.co/C3DbVCAaMT "Bortezomib (BTZ) is a peptide boronic acid that reversibly acts on the chymotrypsin-like activity of the 20S particle."