https://t.co/tqqRSiRiK2 "They discovered that the level of H4K12la was upregulated in Aβ plaque-adjacent microglia; thus, they hypothesized that this increased glycolysis/H4K12la/PKM2 positive feedback loop, which exacerbated microglial dysfunction in AD"
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3,904 followers
https://t.co/tqqRSiRiK2 "A recent study found that lactylation had a role in the etiology of Alzheimer’s disease (AD)."
3,904 followers
https://t.co/tqqRSiRiK2 "Under various disease conditions, such as sepsis, cancer, chronic inflammation, and autoimmune diseases, it has been reported that lactate produced by aerobic glycolysis has immunosuppressive effects in local tissues"
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https://t.co/tqqRSiRiK2 "We hypothesize that cells have a “lactate clock” (Zhang et al., 2019)." "When exogenous or endogenous lactate accumulates to a certain quantity in cells, the “lactate clock” is activated and initiates lysine lactylation."