https://t.co/Ow0hEE8UIZ "Moreover, activation of the SIRT1/PGC-1α/NRF/TFAM signaling pathway improved mitochondrial membrane potential, enhanced cytochrome c oxidase 1 (COX1) activity, and increased mtDNA and ATP content (33, 34)."
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3,459 followers
https://t.co/Ow0hEE8UIZ "SIRT1 was shown to activate PGC-1α and NRF1 to alleviate hyperoxia-induced mitochondrial dysfunction in the lung epithelial cells, thereby reducing apoptosis (5)."
3,459 followers
https://t.co/Ow0hEE8UIZ "TFAM is transferred to mitochondria after nucleogenesis to control mtDNA transcription and replication (31), thus driving the production of mitochondrial respiratory enzymes and membrane proteins, thus promoting mitochondrial biog
3,459 followers
https://t.co/Ow0hEE8UIZ "SIRT1 deacetylation activates PGC-1α, which subsequently activates nuclear respiratory factor 1 (NRF1) and NRF2. NRF1 and NRF2, as cell-important transcription factors, can regulate nuclear DNA (nDNA) to encode mitochondrial transc