The affinity of antigen-binding domain on the antitumor efficacy of CAR T cells: Moderate is better

Overview of attention for article published in Frontiers in immunology, October 2022

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RT @leochicaybam: The never-ending debate on CAR-T affinity :) I tend to agree that moderate is better, but it is highly context-dependent…

The never-ending debate on CAR-T affinity :) I tend to agree that moderate is better, but it is highly context-dependent (target biology, scFv clone) #cartcells #immunotherapy https://t.co/DYjaPh7MSG https://t.co/cnKhqlKAM5

CARたんぱくの抗原認識部位と標的抗原とのアフィニティーは、高すぎても低すぎてもいけなくて、Moderate is betterだと言う論文😃 まさにそのとおりだと思います😌 https://t.co/eDX1klf0ak #週末はCART論文を読む時間です

Goldilocks principle is on T cells, be it CAR-T or TCR-T.

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