Title |
Mutations in the Human AAA+ Chaperone p97 and Related Diseases
|
---|---|
Published in |
Frontiers in Molecular Biosciences, December 2016
|
DOI | 10.3389/fmolb.2016.00079 |
Pubmed ID | |
Authors |
Wai Kwan Tang, Di Xia |
Abstract |
A number of neurodegenerative diseases have been linked to mutations in the human protein p97, an abundant cytosolic AAA(+) (ATPase associated with various cellular activities) ATPase, that functions in a large number of cellular pathways. With the assistance of a variety of cofactors and adaptor proteins, p97 couples the energy of ATP hydrolysis to conformational changes that are necessary for its function. Disease-linked mutations, which are found at the interface between two main domains of p97, have been shown to alter the function of the protein, although the pathogenic mutations do not appear to alter the structure of individual subunit of p97 or the formation of the hexameric biological unit. While exactly how pathogenic mutations alter the cellular function of p97 remains unknown, functional, biochemical and structural differences between wild-type and pathogenic mutants of p97 are being identified. Here, we summarize recent progress in the study of p97 pathogenic mutants. |
X Demographics
As of 1 July 2024, you may notice a temporary increase in the numbers of X profiles with Unknown location. Click here to learn more.
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 1 | 50% |
Members of the public | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 1% |
Unknown | 83 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 18 | 21% |
Researcher | 13 | 15% |
Student > Bachelor | 13 | 15% |
Student > Master | 6 | 7% |
Student > Postgraduate | 5 | 6% |
Other | 14 | 17% |
Unknown | 15 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 29 | 35% |
Agricultural and Biological Sciences | 11 | 13% |
Neuroscience | 10 | 12% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 5% |
Chemistry | 4 | 5% |
Other | 12 | 14% |
Unknown | 14 | 17% |