Hyperuricemia contributes to glucose intolerance of hepatic inflammatory macrophages and impairs the insulin signaling pathway via IRS2-proteasome degradation

Hyperuricemia contributes to glucose intolerance of inflammatory macrophages & impairs insulin signaling via IRS2-proteasome degradation —HUA inhibited nuclear translocation of GLUT-4 in hepatic macrophages, lowered insulin-induced glucose uptake/toler