@sh_akers Doubt histamine (H) can be depleted, unless dietary histidine is eliminated. The flush prob abates due to downregulation of the H receptor by repeated H release. Btw, the main ligand for GPR109A is beta-OH-butyrate, so GPR109A agonism prob not a
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Niacin exacerbates β cell #lipotoxicity in diet-induced #obesity mice through upregulation of GPR109A and PPARγ2: Inhibition by incretin drugs @FrontEndocrinol https://t.co/pN3S8n7vPg
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RT @FrontEndocrinol: New Research: Niacin exacerbates β cell lipotoxicity in diet-induced obesity mice through upregulation of GPR109A and…
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RT @Brunorm84: Niacin exacerbates β cell #lipotoxicity in diet-induced #obesity mice through upregulation of GPR109A and PPARγ2: Inhibition…