Effect of lactic acid on immune cells in the tumor microenvironment of CRC.. https://t.co/vKOQaPyfOV
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RT @khristaki: Hypoxic & acidified tumor microenvironment giving rise to (excess lactate) lactic acidosis & excessive glycolysis, epigeneti…
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𝗟𝗮𝗰𝘁𝗮𝘁𝗲, 𝗶𝗺𝗺𝘂𝗻𝗲 𝗿𝗲𝗴𝘂𝗹𝗮𝘁𝗶𝗼𝗻 𝗮𝗻𝗱 𝘁𝗵𝗲𝗿𝗮𝗽𝗲𝘂𝘁𝗶𝗰 𝗼𝘂𝘁𝗰𝗼𝗺𝗲 𝗶𝗻 𝗰𝗼𝗹𝗼𝗿𝗲𝗰𝘁𝗮𝗹 𝗰𝗮𝗻𝗰𝗲𝗿 It is well-established that increased glycolysis and by that virtue production of lactate is an…https://t.co/zsnWq2Mf8R https://t.co/yv0AIG7X5Q
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Hypoxic & acidified tumor microenvironment giving rise to (excess lactate) lactic acidosis & excessive glycolysis, epigenetically shifts (w/VEGF & Arginase) metabolism/signaling through polarization of macrophages (Mφ) into pro-tumor and immune