Fecal microbiome transplantation and tributyrin improves early cardiac dysfunction and modifies the BCAA metabolic pathway in a diet induced pre-HFpEF mouse model

RT @renesugar: Fecal microbiome transplantation and tributyrin improves early cardiac dysfunction and modifies the BCAA metabolic pathway i…

https://t.co/GFax61MuFA "These findings show that gut microbiome modulation can alleviate early cardiac mechanics dysfunction seen in the development of obesity associated HFpEF."

https://t.co/GFax61MuFA "and in turn increases the catabolism of branched chain amino acids (BCAAs)." #BCAA "Following both FMT and butyrate treatment, the level of inactive p-BCKDH in the heart was reduced." #BCKDH

https://t.co/GFax61MuFA "Cardiac RNAseq analysis showed butyrate to significantly upregulate ppm1k gene that encodes protein phosphatase 2Cm (PP2Cm) which dephosphorylates and activates branched-chain α-keto acid dehydrogenase (#BCKDH) enzyme,"