"Reprogramming of IL-12 secretion in the PDCD1 locus improves the anti-tumor activity of NY-ESO-1 TCR-T cells" Kim S, Park CI, Lee S, Choi HR, Kim CH. Front Immune. 2023-01-30. https://t.co/1KgsOy3qQ9 #CRISPR/Cas9; ΔPD-1-[IL-12 KI] NY-ESO-1 TCR-T cell
RT @CRISPR_papers: Reprogramming of IL-12 secretion in the PDCD1 locus improves the anti-tumor activity of NY-ESO-1 TCR-T cells https://t.c…
Reprogramming of IL-12 secretion in the PDCD1 locus improves the anti-tumor activity of NY-ESO-1 TCR-T cells https://t.co/U1YYHUgFmP
Paper from our lab published at the end of last month! The first author, Segi, exploited tightly regulated PDCD-1 expression mechanism to reversely enhance TCR-T cells while turning off inhibitory signaling. https://t.co/CTlasMzcHW