Title |
Oxidative Burst-Dependent NETosis Is Implicated in the Resolution of Necrosis-Associated Sterile Inflammation
|
---|---|
Published in |
Frontiers in immunology, December 2016
|
DOI | 10.3389/fimmu.2016.00557 |
Pubmed ID | |
Authors |
Mona H. C. Biermann, Malgorzata J. Podolska, Jasmin Knopf, Christiane Reinwald, Daniela Weidner, Christian Maueröder, Jonas Hahn, Deborah Kienhöfer, Alexandre Barras, Rabah Boukherroub, Sabine Szunerits, Rostyslav Bilyy, Markus Hoffmann, Yi Zhao, Georg Schett, Martin Herrmann, Luis E. Munoz |
Abstract |
Necrosis is associated with a profound inflammatory response. The regulation of necrosis-associated inflammation, particularly the mechanisms responsible for resolution of inflammation is incompletely characterized. Nanoparticles are known to induce plasma membrane damage and necrosis followed by sterile inflammation. We observed that injection of metabolically inert nanodiamonds resulted in paw edema in WT and Ncf1** mice. However, while inflammation quickly resolved in WT mice, it persisted over several weeks in Ncf1** mice indicating failure of resolution of inflammation. Mechanistically, NOX2-dependent reactive oxygen species (ROS) production and formation of neutrophil extracellular traps were essential for the resolution of necrosis-induced inflammation: hence, by evaluating the fate of the particles at the site of inflammation, we observed that Ncf1** mice deficient in NADPH-dependent ROS failed to generate granulation tissue therefore being unable to trap the nanodiamonds. These data suggest that NOX2-dependent NETosis is crucial for preventing the chronification of the inflammatory response to tissue necrosis by forming NETosis-dependent barriers between the necrotic and healthy surrounding tissue. |
X Demographics
As of 1 July 2024, you may notice a temporary increase in the numbers of X profiles with Unknown location. Click here to learn more.
Geographical breakdown
Country | Count | As % |
---|---|---|
Australia | 1 | 50% |
Switzerland | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 1 | 50% |
Members of the public | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 49 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 12 | 24% |
Student > Ph. D. Student | 7 | 14% |
Student > Master | 6 | 12% |
Student > Bachelor | 5 | 10% |
Professor | 4 | 8% |
Other | 8 | 16% |
Unknown | 7 | 14% |
Readers by discipline | Count | As % |
---|---|---|
Immunology and Microbiology | 12 | 24% |
Biochemistry, Genetics and Molecular Biology | 10 | 20% |
Agricultural and Biological Sciences | 7 | 14% |
Engineering | 3 | 6% |
Medicine and Dentistry | 3 | 6% |
Other | 4 | 8% |
Unknown | 10 | 20% |