Suvorexant Acutely Decreases Tau Phosphorylation and Aβ in the Human CNS https://t.co/8RosaAKlX3 https://t.co/25QzdhfBTX
6,857 followers
575 followers
small RCT: suvorexant 20 mg, a dual orexin r. antag., ↓ the CSF ratio of phosphorylated-tau-threonine-181 to unphosphorylated ~10% to 15% vs. placebo. Phosphorylation at tau-serine-202 and -217 were not ↓. Suvorexant ↓ amyloid-β ~10% to 20% vs. placebo htt
293 followers
Study: Insomnia drug suvorexant may reduce Alzheimer’s proteins amyloid-β & tau in cerebrospinal fluid. NIH to test further in dementia risk patients.
360 followers
RT @AMahajanMD: Suvorexant, a dual orexin receptor antagonist ✅acutely decreased tau phosphorylation at T181 and Aβ levels in human CSF ✅…