Mutagenic analysis of actin reveals the mechanism of His161 flipping that triggers ATP hydrolysis

Overview of attention for article published in Frontiers in Cell and Developmental Biology, March 2023

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アクチン変異体の構造解析より、アクチンのHis161がA108/P109との立体障害を回避するようにフリップしてATPが加水分解されると示したまた、ATPase活性が低下するQ137A変異では活性中心の水の配置に影響がないことから、水分子の揺らぎが活性低下に寄与すると示唆した #BNTNJC https://t.co/xa1XubFbYE

23 Apr 2023

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New Research: Mutagenic analysis of actin reveals the mechanism of His161 flipping that triggers ATP hydrolysis: The dynamic assembly of actin is controlled by the hydrolysis of ATP, bound to the center of the molecule. Upon polymerization,… https://t.co/6

17 Mar 2023

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