@MarionKoopmans Taken together, these data demonstrate the presence of pre-pandemic cross-reactive IFN-γ in this population, implying that the immune system had been primed to respond to SARS-CoV-2 antigens prior to the outbreak. https://t.co/vlPL3ENmJk
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257 followers
@MarionKoopmans Uganda proves there’s no such thing as OC43 or 229E T cell cross-protection, but most probably HKU5. Can you explain what this means for future vaccines and interpretation of covid-19 epidemiology, retrospectively and future? https://t.co
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@2dedostesta2 @kanibalgrumpy @ejustin46 The cross-reactivity is (my thesis) against HKU5 (Uganda). https://t.co/aTjaA7HcF3 https://t.co/DemD3GtM4Y
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Pre-pandemic SARS-CoV-2-specific IFN-γ and antibody responses were low in Ugandan samples and significantly reduced in HIV-positive specimens https://t.co/ipZoV4oCqP