Chapter title |
Exosome-Based COVID-19 Vaccine.
|
---|---|
Chapter number | 20 |
Book title |
Cell-Secreted Vesicles
|
Published in |
Methods in molecular biology, January 2023
|
DOI | 10.1007/978-1-0716-3203-1_20 |
Pubmed ID | |
Book ISBNs |
978-1-07-163202-4, 978-1-07-163203-1
|
Authors |
Kim, Jaeyoung, Thapa, Nikita |
Abstract |
Extracellular vesicles (EVs) enable cell-to-cell communication and, by delivering antigens, can stimulate the immune response strongly. Approved in use SARS-CoV-2 vaccine, candidates immunize with the viral spike protein delivered via viral vectors, translated by injected mRNAs, or as a pure protein. Here, we outline a novel methodological approach for generating SARS-CoV-2 vaccine using exosome that delivers antigens from the SARS-CoV-2 structural proteins. Engineered EVs can be loaded with viral antigens, thus acting as antigens presenting EVs, eliciting strong and targeted CD8(+) T cell and B cell, offering a unique approach to vaccine development. Engineered EVs thus portray a safe, adaptable, and effective approach for a virus-free vaccine development. |
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Unknown | 1 | 100% |
Demographic breakdown
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
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Unknown | 5 | 100% |
Demographic breakdown
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Researcher | 2 | 40% |
Student > Bachelor | 1 | 20% |
Student > Ph. D. Student | 1 | 20% |
Unknown | 1 | 20% |
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Biochemistry, Genetics and Molecular Biology | 2 | 40% |
Engineering | 1 | 20% |
Unknown | 2 | 40% |