@MasriAhmadMD It's a lot of work, but ... Fluo4 is a myosin inhibitor https://t.co/skkXoEsfIX The Ca++ impact of myofilament mutations/drugs are better seen at the myofilament https://t.co/XKEVcOzMcG This includes in combination testing https://t.c
But not everything worked out as planned. A 40y old platform I thought could be trusted turned out to have major problems, & getting that published became a nightmare that started to derail academic career progression https://t.co/wEDwyjjCcZ 4/
@joachimgoedhart @MattNeuro @Lab_Nagai made an inverse pericam https://t.co/aC3f2JbDUT Which was improved in 2018 https://t.co/99VV4XBgdZ Avoid the chemical dyes if you can - they do bad things to some important ATPases that you can avoid https://t.c
@NatRevDrugDisc It's not just the drugs used in the experiments It's also the compounds that sometimes enable the experiment in the first place Chemical calcium (& voltage) indicators being a good example used in tens of thousands of papers to date