ステロイド難治性の甲状腺眼症に対しトシリズマブ投与で、80%以上の人でcas下げ、眼球突出も2mm程度減ったという報告。12人に対し8mg/kgを4週間おき、4ヶ月投与。複視は改善見られず。重大な副作用なし。2023年6月の論文 https://t.co/RB5l9xk6B3).-,Outcomes,2%20mm%2C%20and%20diplopia%20response.
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After corticosteroids had failed, IV Actemra (tocilizumab) was called in to rescue 12 patients with Graves' orbitopathy. "The primary outcome was achieved in all 12 patients...radiological improvement in 75%, 16.7% showed no response, 8.3% deteriorated" h
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New Research: Tocilizumab improves clinical outcome in patients with active corticosteroid-resistant moderate-to-severe Graves’ orbitopathy: an observational study: Background Graves’ orbitopathy (GO) is an autoimmune disorder… #Endocrinology #Endo https: