Branched-chain amino acids catabolism and cancer progression: focus on therapeutic interventions

https://t.co/2Dw02hp76R "Additionally, the absence of enzymes synthesizing BCKAs from the de novo pathway makes it impossible to produce BCAAs in the body."

https://t.co/2Dw02hp76R "Specifically, valine catabolism yields propionyl-CoA, leucine generates acetyl-CoA and acetoacetate, and isoleucine produces acetyl-CoA and propionyl-CoA." "In mammals, the activity of BCKDH is irreversible."

https://t.co/2Dw02hp76R "including isovaleryl-CoA, 2-methylbutyryl-CoA, and isobutyryl-CoA in various cells and tissues." "These acyl-CoA derivatives are metabolized through distinct pathways."

https://t.co/2Dw02hp76R "A multimeric enzyme complex called BCKA dehydrogenase (BCKDH), which consists of E1, E2, and E3 subunits, catalyzes the oxidative decarboxylation of BCKAs to generate acyl-CoA derivatives,"