Title |
Neutralizing Monoclonal Antibodies to Fight HIV-1: On the Threshold of Success
|
---|---|
Published in |
Frontiers in immunology, January 2017
|
DOI | 10.3389/fimmu.2016.00661 |
Pubmed ID | |
Authors |
Juan Pablo Jaworski, Alejandrina Vendrell, Sebastián Matias Chiavenna |
Abstract |
Anti-human immunodeficiency virus type-1 (anti-HIV-1) neutralizing monoclonal antibodies are broadening the spectrum of pre- and post-exposure treatment against HIV-1. A better understanding of how these antibodies develop and interact with particular regions of the viral envelope protein is guiding a more rational structure-based immunogen design. The aim of this article is to review the most recent advances in the field, from the development of these particular antibodies during natural HIV-1 infection, to their role preventing infection, boosting endogenous immune responses and clearing both free viral particles and persistently infected cells. |
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Country | Count | As % |
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United States | 1 | 9% |
Spain | 1 | 9% |
Argentina | 1 | 9% |
Unknown | 8 | 73% |
Demographic breakdown
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Scientists | 1 | 9% |
Practitioners (doctors, other healthcare professionals) | 1 | 9% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 26 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 8 | 31% |
Student > Ph. D. Student | 5 | 19% |
Other | 3 | 12% |
Student > Doctoral Student | 2 | 8% |
Student > Bachelor | 2 | 8% |
Other | 3 | 12% |
Unknown | 3 | 12% |
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Medicine and Dentistry | 5 | 19% |
Unknown | 5 | 19% |