Enhancement of prostaglandin D2-D prostanoid 1 signaling reduces intestinal permeability by stimulating mucus secretion

RT @renesugar: Enhancement of prostaglandin D2-D prostanoid 1 signaling reduces intestinal permeability by stimulating mucus secretion #PGD…

https://t.co/hMRI1QiCQn "DP1 stimulation did not affect TER in vitro but induced mucus secretion from goblet cells." "Mucus removal by a mucolytic agent N-acetyl-l-cysteine canceled the inhibition of intestinal permeability by DP1 stimulation." #NAC

https://t.co/hMRI1QiCQn "Pharmacological DP1 stimulation reduced intestinal permeability both in vivo and ex vivo." "Immunohistochemical staining showed that DP1 was strongly expressed on the apical side of the epithelial cells."

https://t.co/hMRI1QiCQn "We previously reported that pharmacological stimulation of PGD2 receptor, D prostanoid 1 (DP1) attenuated the symptoms of azoxymethane/dextran sodium sulfate-induced colitis and ovalbumin-induced food allergy in mouse models."