P38 mitogen-activated protein kinase (P38 MAPK), protein kinase B (AKT), and the nuclear factor-κB (NF-κB) pathway. This figure outlines the effects of gut microbes and their metabolites on microglia through the aforementioned signaling pathways https://t.
Mechanisms of gut flora-derived metabolite regulation of microglia activation. Microglia activation is closely tied to various signaling pathways, including extracellular signal-regulated protein kinases (ERK), c-Jun N-terminal kinase (JNK), (...) https:/
In the course of AD progression, increased activation of microglia leads to the generation of pro-inflammatory factors that detrimentally affect neurons and their synaptic connections. https://t.co/eO9n2a4eEA https://t.co/ehqjHwoF3D
Intestinal microbes and their metabolites play a crucial role in maintaining central nervous system homeostasis by modulating microglial activation, thereby influencing the clearance of Aβ and Tau proteins. https://t.co/eO9n2a4eEA https://t.co/pkwaLVHlUa