Title |
Single-Cell Transcription Mapping of Murine and Human Mammary Organoids Responses to Female Hormones
|
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Published in |
Journal of Mammary Gland Biology and Neoplasia, January 2024
|
DOI | 10.1007/s10911-023-09553-x |
Pubmed ID | |
Authors |
Jenelys Ruiz Ortiz, Steven M. Lewis, Michael Ciccone, Deeptiman Chatterjee, Samantha Henry, Adam Siepel, Camila O. dos Santos |
Abstract |
During female adolescence and pregnancy, rising levels of hormones result in a cyclic source of signals that control the development of mammary tissue. While such alterations are well understood from a whole-gland perspective, the alterations that such hormones bring to organoid cultures derived from mammary glands have yet to be fully mapped. This is of special importance given that organoids are considered suitable systems to understand cross species breast development. Here we utilized single-cell transcriptional profiling to delineate responses of murine and human normal breast organoid systems to female hormones across evolutionary distinct species. Collectively, our study represents a molecular atlas of epithelial dynamics in response to estrogen and pregnancy hormones. |
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Geographical breakdown
Country | Count | As % |
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United States | 3 | 13% |
Unknown | 21 | 88% |
Demographic breakdown
Type | Count | As % |
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Scientists | 14 | 58% |
Members of the public | 6 | 25% |
Science communicators (journalists, bloggers, editors) | 4 | 17% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 11 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Unspecified | 3 | 27% |
Student > Ph. D. Student | 3 | 27% |
Professor | 1 | 9% |
Other | 1 | 9% |
Unknown | 3 | 27% |
Readers by discipline | Count | As % |
---|---|---|
Unspecified | 3 | 27% |
Biochemistry, Genetics and Molecular Biology | 3 | 27% |
Medicine and Dentistry | 1 | 9% |
Unknown | 4 | 36% |