'...reprogramming of non-limb fibroblasts to ... limb progenitors' by 4 embryonic neural factors, Prdm16/Zbtb16/Lin28/Lin41. @Dev_Cell Coincidental? Maybe not. Because differentiation potential is determined by neural stemness/neural regulatory network.
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関連論文: Atsuta, Y., et al. (2024). Direct reprogramming of non-limb fibroblasts to cells with properties of limb progenitors. Developmental Cell 59, 415-430, https://t.co/JsCVe9RWxO
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We can regrow limbs soon https://t.co/fGJZXGKdpX
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📰Recently it was achieved direct reprogramming of fibroblasts into mesenchymal limb progenitors with similar expression of the limb progenitors found in limb buds of mouse embryos! Reprograming with Prdm16, Zbtb16, Lin28a (Lin41 enhances it) @Dev_Cell h