Alpha-lipoic acid upregulates antioxidant enzyme gene expression and enzymatic activity in diabetic rat kidneys through an O-GlcNAc-dependent mechanism

RT @renesugar: Alpha-lipoic acid upregulates antioxidant enzyme gene expression and enzymatic activity in diabetic rat kidneys through an O…

α-Lipoic acid administration decreased O-GlcNAcylation "Although it was shown that LA treatment induces ERK and p38 activation, our results suggest that this induction correlated with the hypoglycemic effect of LA and decreased O-GlcNAcylation." https://

https://t.co/waZ4d6b5y2 "α-Lipoic acid administration activates a coordinated cytoprotective response against diabetes-induced oxidative injury in kidney tissue through an O-GlcNAc-dependent mechanism."

https://t.co/waZ4d6b5y2 "The changes observed after LA treatment represent a coordinated renal cytoprotective cellular response against diabetes-induced oxidative stress in kidney tissue."