Title |
Pref-1, a Gatekeeper of Adipogenesis
|
---|---|
Published in |
Frontiers in endocrinology, January 2013
|
DOI | 10.3389/fendo.2013.00079 |
Pubmed ID | |
Authors |
Carolyn S. Hudak, Hei Sook Sul |
Abstract |
Preadipocyte factor 1 (Pref-1, also called Dlk1/FA1) is a molecular gatekeeper of adipogenesis which acts by maintaining the preadipocyte state and preventing adipocyte differentiation. Pref-1 is made as an epidermal growth factor-like repeat containing transmembrane protein, and is cleaved by TNFα-converting enzyme (TACE) to generate a soluble form, which acts as an autocrine/paracrine factor. Pref-1 upregulates Sox9 expression by activating the ERK/MAPK pathway and the Pref-1 interaction with fibronectin is required for inhibition of adipogenesis. Pref-1 also prevents brown adipocyte differentiation and its thermogenic function. Here, we highlight the recent evidence for the role of Pref-1 in adipogenesis. |
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Mendeley readers
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Demographic breakdown
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Researcher | 22 | 14% |
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Other | 15 | 9% |
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