Title |
Single-dose radiosurgical treatment for hepatic metastases - therapeutic outcome of 138 treated lesions from a single institution
|
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Published in |
Radiation Oncology, July 2013
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DOI | 10.1186/1748-717x-8-175 |
Pubmed ID | |
Authors |
Daniel Habermehl, Klaus K Herfarth, Justo Lorenzo Bermejo, Holger Hof, Stefan Rieken, Sabine Kuhn, Thomas Welzel, Jürgen Debus, Stephanie E Combs |
Abstract |
Local ablative therapies such as stereotactically guided single-dose radiotherapy or helical intensity-modulated radiotherapy (tomotherapy) with high single-doses are successfully applied in many centers in patients with liver metastasis not suitable for surgical resection. This study presents results from more than 10 years of clinical experience and evaluates long-term outcome and efficacy of this therapeutic approach.Patients and methodsFrom 1997 to 2009 a total of 138 intrahepatic tumors of 90 patients were irradiated with single doses of 17 to 30 Gy (median dose 24 Gy). Median age of the patients was 64 years (range 31--89 years). Most frequent underlying tumor histologies were colorectal adenocarcinoma (70 lesions) and breast cancer (27 lesions). In 35 treatment sessions multiple targets up to four lesions at once were irradiated simultaneously. Local progression-free (PFS) and overall survival (OS) from treatment day on were investigated using uni- and multivariable survival regression models. |
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