Title |
Retinoid X Receptors Intersect the Molecular Clockwork in the Regulation of Liver Metabolism
|
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Published in |
Frontiers in endocrinology, February 2017
|
DOI | 10.3389/fendo.2017.00024 |
Pubmed ID | |
Authors |
Salvatore De Cosmo, Gianluigi Mazzoccoli |
Abstract |
Liver metabolic pathways are driven by the biological clock, and appropriate timing of 24-h patterns of metabolic gene expression as well as anabolic/catabolic processes with wake-related activity/feeding and sleep-related resting/fasting cycles preserves hepatic healthiness. The interplay among the liver metabolic pathways and the molecular clockwork is geared by the nuclear receptors, and ligand-dependent transcription factors that gauge the cellular nutritional status and redox balance, bind hormones and metabolites, and modulate the transcription of thousands target genes through their DNA-binding domain. Several nuclear receptors in the liver oscillate with circadian rhythmicity, and among these, the retinoid X receptors play a key role in metabolism regulation, intersecting with the cogs of the molecular clockwork. |
X Demographics
As of 1 July 2024, you may notice a temporary increase in the numbers of X profiles with Unknown location. Click here to learn more.
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 33% |
Unknown | 4 | 67% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 4 | 67% |
Scientists | 2 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Netherlands | 1 | 3% |
Unknown | 39 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 9 | 23% |
Researcher | 7 | 18% |
Student > Master | 6 | 15% |
Student > Bachelor | 3 | 8% |
Student > Doctoral Student | 1 | 3% |
Other | 4 | 10% |
Unknown | 10 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 12 | 30% |
Agricultural and Biological Sciences | 7 | 18% |
Immunology and Microbiology | 3 | 8% |
Medicine and Dentistry | 3 | 8% |
Neuroscience | 2 | 5% |
Other | 2 | 5% |
Unknown | 11 | 28% |