Title |
Molecular anatomy of the gut-brain axis revealed with transgenic technologies: implications in metabolic research
|
---|---|
Published in |
Frontiers in Neuroscience, January 2013
|
DOI | 10.3389/fnins.2013.00134 |
Pubmed ID | |
Authors |
Swalpa Udit, Laurent Gautron |
Abstract |
Neurons residing in the gut-brain axis remain understudied despite their important role in coordinating metabolic functions. This lack of knowledge is observed, in part, because labeling gut-brain axis neurons and their connections using conventional neuroanatomical methods is inherently challenging. This article summarizes genetic approaches that enable the labeling of distinct populations of gut-brain axis neurons in living laboratory rodents. In particular, we review the respective strengths and limitations of currently available genetic and viral approaches that permit the marking of gut-brain axis neurons without the need for antibodies or conventional neurotropic tracers. Finally, we discuss how these methodological advances are progressively transforming the study of the healthy and diseased gut-brain axis in the context of its role in chronic metabolic diseases, including diabetes and obesity. |
X Demographics
As of 1 July 2024, you may notice a temporary increase in the numbers of X profiles with Unknown location. Click here to learn more.
Geographical breakdown
Country | Count | As % |
---|---|---|
Mexico | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 1 | 50% |
Members of the public | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 1% |
Germany | 1 | <1% |
France | 1 | <1% |
Portugal | 1 | <1% |
United Kingdom | 1 | <1% |
Finland | 1 | <1% |
Korea, Republic of | 1 | <1% |
Argentina | 1 | <1% |
Unknown | 138 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 31 | 21% |
Researcher | 23 | 16% |
Student > Bachelor | 20 | 14% |
Student > Master | 18 | 12% |
Professor > Associate Professor | 9 | 6% |
Other | 30 | 20% |
Unknown | 16 | 11% |
Readers by discipline | Count | As % |
---|---|---|
Neuroscience | 33 | 22% |
Agricultural and Biological Sciences | 26 | 18% |
Medicine and Dentistry | 25 | 17% |
Biochemistry, Genetics and Molecular Biology | 18 | 12% |
Immunology and Microbiology | 5 | 3% |
Other | 20 | 14% |
Unknown | 20 | 14% |