Title |
Understanding Physiology in the Continuum: Integration of Information from Multiple -Omics Levels
|
---|---|
Published in |
Frontiers in Pharmacology, February 2017
|
DOI | 10.3389/fphar.2017.00091 |
Pubmed ID | |
Authors |
Kubra Kamisoglu, Alison Acevedo, Richard R. Almon, Susette Coyle, Siobhan Corbett, Debra C. Dubois, Tung T. Nguyen, William J. Jusko, Ioannis P. Androulakis |
Abstract |
In this paper, we discuss approaches for integrating biological information reflecting diverse physiologic levels. In particular, we explore statistical and model-based methods for integrating transcriptomic, proteomic and metabolomics data. Our case studies reflect responses to a systemic inflammatory stimulus and in response to an anti-inflammatory treatment. Our paper serves partly as a review of existing methods and partly as a means to demonstrate, using case studies related to human endotoxemia and response to methylprednisolone (MPL) treatment, how specific questions may require specific methods, thus emphasizing the non-uniqueness of the approaches. Finally, we explore novel ways for integrating -omics information with PKPD models, toward the development of more integrated pharmacology models. |
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