Title |
Myeloid and T Cell-Derived TNF Protects against Central Nervous System Tuberculosis
|
---|---|
Published in |
Frontiers in immunology, February 2017
|
DOI | 10.3389/fimmu.2017.00180 |
Pubmed ID | |
Authors |
Nai-Jen Hsu, Ngiambudulu M. Francisco, Roanne Keeton, Nasiema Allie, Valérie F. J. Quesniaux, Bernhard Ryffel, Muazzam Jacobs |
Abstract |
Tuberculosis of the central nervous system (CNS-TB) is a devastating complication of tuberculosis, and tumor necrosis factor (TNF) is crucial for innate immunity and controlling the infection. TNF is produced by many cell types upon activation, in particularly the myeloid and T cells during neuroinflammation. Here we used mice with TNF ablation targeted to myeloid and T cell (MT-TNF(-/-)) to assess the contribution of myeloid and T cell-derived TNF in immune responses during CNS-TB. These mice exhibited impaired innate immunity and high susceptibility to cerebral Mycobacterium tuberculosis infection, a similar phenotype to complete TNF-deficient mice. Further, MT-TNF(-/-) mice were not able to control T cell responses and cytokine/chemokine production. Thus, our data suggested that collective TNF production by both myeloid and T cells are required to provide overall protective immunity against CNS-TB infection. |
X Demographics
As of 1 July 2024, you may notice a temporary increase in the numbers of X profiles with Unknown location. Click here to learn more.
Geographical breakdown
Country | Count | As % |
---|---|---|
Korea, Democratic People's Republic of | 1 | 25% |
Spain | 1 | 25% |
Switzerland | 1 | 25% |
Unknown | 1 | 25% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 50% |
Scientists | 1 | 25% |
Practitioners (doctors, other healthcare professionals) | 1 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 18 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 4 | 22% |
Student > Doctoral Student | 2 | 11% |
Student > Bachelor | 2 | 11% |
Other | 1 | 6% |
Student > Ph. D. Student | 1 | 6% |
Other | 3 | 17% |
Unknown | 5 | 28% |
Readers by discipline | Count | As % |
---|---|---|
Immunology and Microbiology | 5 | 28% |
Biochemistry, Genetics and Molecular Biology | 2 | 11% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 6% |
Unspecified | 1 | 6% |
Arts and Humanities | 1 | 6% |
Other | 4 | 22% |
Unknown | 4 | 22% |