Title |
Lesions of the Orbitofrontal but Not Medial Prefrontal Cortex Affect Cognitive Judgment Bias in Rats
|
---|---|
Published in |
Frontiers in Behavioral Neuroscience, March 2017
|
DOI | 10.3389/fnbeh.2017.00051 |
Pubmed ID | |
Authors |
Joanna Golebiowska, Rafal Rygula |
Abstract |
Neuroimaging studies in humans have recently shown that the prefrontal cortex (PFC) and orbitofrontal cortex (OFC) mediate bias in the judgment of forthcoming events. In the present study, we sought to determine whether cognitive judgment bias (CJB) is also dependent on these prefrontal regions in non-human animals. For this, we trained a cohort of rats in the ambiguous-cue interpretation (ACI) paradigm, subjected them to excitotoxic lesions in the medial PFC (mPFC) and OFC, and tested the effects of neuronal loss within these regions on CJB. Comparison of the lesions' behavioral effects in the ACI paradigm revealed that neuronal loss within the OFC but not within the mPFC influences the interpretation of ambiguous cues by animals. Our findings demonstrate the specific involvement of the OFC in CJB in rats. |
X Demographics
As of 1 July 2024, you may notice a temporary increase in the numbers of X profiles with Unknown location. Click here to learn more.
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 33% |
Unknown | 4 | 67% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 6 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 28 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 9 | 32% |
Student > Ph. D. Student | 8 | 29% |
Student > Master | 5 | 18% |
Researcher | 2 | 7% |
Librarian | 1 | 4% |
Other | 0 | 0% |
Unknown | 3 | 11% |
Readers by discipline | Count | As % |
---|---|---|
Neuroscience | 8 | 29% |
Psychology | 7 | 25% |
Agricultural and Biological Sciences | 4 | 14% |
Economics, Econometrics and Finance | 2 | 7% |
Social Sciences | 1 | 4% |
Other | 2 | 7% |
Unknown | 4 | 14% |