Ramil Afzalov, Evgeny Pryazhnikov, Pei-Yu Shih, Elena Kondratskaya, Svetlana Zobova, Sakari Leino, Outi Salminen, Leonard Khiroug, Alexey Semyanov
Abstract
Glutamate uptake, mediated by electrogenic glutamate transporters largely localized in astrocytes, is responsible for the clearance of glutamate released during excitatory synaptic transmission. Glutamate uptake also determines the availability of glutamate for extrasynaptic glutamate receptors. The efficiency of glutamate uptake is commonly estimated from the amplitude of transporter current recorded in astrocytes. We recorded currents in voltage-clamped hippocampal CA1 stratum radiatum astrocytes in rat hippocampal slices induced by electrical stimulation of the Schaffer collaterals. A Ba(2+)-sensitive K(+) current mediated by inward rectifying potassium channels (Kir) accompanied the transporter current. Surprisingly, Ba(2+) not only suppressed the K(+) current and changed holding current (presumably, mediated by Kir) but also increased the transporter current at lower concentrations. However, Ba(2+) did not significantly increase the uptake of aspartate in cultured astrocytes, suggesting that increase in the amplitude of the transporter current does not always reflect changes in glutamate uptake.
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 March 2014.
All research outputs
#13,157,888
of 22,719,618 outputs
Outputs from Frontiers in Cellular Neuroscience
#1,737
of 4,213 outputs
Outputs of similar age
#155,800
of 280,759 outputs
Outputs of similar age from Frontiers in Cellular Neuroscience
#79
of 203 outputs
Altmetric has tracked 22,719,618 research outputs across all sources so far. This one is in the 41st percentile – i.e., 41% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,213 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.2. This one has gotten more attention than average, scoring higher than 56% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 280,759 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 44th percentile – i.e., 44% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 203 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 60% of its contemporaries.
