Title |
Type I and III Interferon in the Gut: Tight Balance between Host Protection and Immunopathology
|
---|---|
Published in |
Frontiers in immunology, March 2017
|
DOI | 10.3389/fimmu.2017.00258 |
Pubmed ID | |
Authors |
Johanna Pott, Silvia Stockinger |
Abstract |
The intestinal mucosa forms an active interface to the outside word, facilitating nutrient and water uptake and at the same time acts as a barrier toward the highly colonized intestinal lumen. A tight balance of the mucosal immune system is essential to tolerate harmless antigens derived from food or commensals and to effectively defend against potentially dangerous pathogens. Interferons (IFN) provide a first line of host defense when cells detect an invading organism. Whereas type I IFN were discovered almost 60 years ago, type III IFN were only identified in the early 2000s. It was initially thought that type I IFN and type III IFN performed largely redundant functions. However, it is becoming increasingly clear that type III IFN exert distinct and non-redundant functions compared to type I IFN, especially in mucosal tissues. Here, we review recent progress made in unraveling the role of type I/III IFN in intestinal mucosal tissue in the steady state, in response to mucosal pathogens and during inflammation. |
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Mendeley readers
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Other | 14 | 11% |
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