Title |
IFN-λ Inhibits Drug-Resistant HIV Infection of Macrophages
|
---|---|
Published in |
Frontiers in immunology, March 2017
|
DOI | 10.3389/fimmu.2017.00210 |
Pubmed ID | |
Authors |
Xu Wang, He Wang, Man-Qing Liu, Jie-Liang Li, Run-Hong Zhou, Yu Zhou, Yi-Zhong Wang, Wang Zhou, Wen-Zhe Ho |
Abstract |
Type III interferons (IFN-λs) have been demonstrated to inhibit a number of viruses, including HIV. Here, we further examined the anti-HIV effect of IFN-λs in macrophages. We found that IFN-λs synergistically enhanced anti-HIV activity of antiretrovirals [azidothymidine (AZT), efavirenz, indinavir, and enfuvirtide] in infected macrophages. Importantly, IFN-λs could suppress HIV infection of macrophages with the drug-resistant strains, including AZT-resistant virus (A012) and reverse transcriptase inhibitor-resistant virus (TC49). Mechanistically, IFN-λs were able to induce the expression of several important anti-HIV cellular factors, including myxovirus resistance 2 (Mx2), a newly identified HIV post-entry inhibitor and tetherin, a restriction factor that blocks HIV release from infected cells. These observations provide additional evidence to support the potential use of IFN-λs as therapeutics agents for the treatment of HIV infection. |
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