Title |
Tumor Delivery of Chemotherapy Combined with Inhibitors of Angiogenesis and Vascular Targeting Agents
|
---|---|
Published in |
Frontiers in oncology, January 2013
|
DOI | 10.3389/fonc.2013.00259 |
Pubmed ID | |
Authors |
Marta Cesca, Francesca Bizzaro, Massimo Zucchetti, Raffaella Giavazzi |
Abstract |
Numerous angiogenesis-vascular targeting agents have been admitted to the ranks of cancer therapeutics; most are used in polytherapy regimens. This review looks at recent progress and our own preclinical experience in combining angiogenesis inhibitors, mainly acting on VEGF/VEGFR pathways, and vascular targeting agents with conventional chemotherapy, discussing the factors that determine the outcome of these treatments. Molecular and morphological modifications of the tumor microenvironment associated with drug distribution and activity are reviewed. Modalities to improve drug delivery and strategies for optimizing combination therapy are examined. |
X Demographics
As of 1 July 2024, you may notice a temporary increase in the numbers of X profiles with Unknown location. Click here to learn more.
Geographical breakdown
Country | Count | As % |
---|---|---|
Ireland | 1 | 33% |
Switzerland | 1 | 33% |
Unknown | 1 | 33% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 67% |
Practitioners (doctors, other healthcare professionals) | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 4% |
Unknown | 53 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 13 | 24% |
Researcher | 9 | 16% |
Student > Bachelor | 7 | 13% |
Other | 6 | 11% |
Student > Master | 5 | 9% |
Other | 6 | 11% |
Unknown | 9 | 16% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 15 | 27% |
Medicine and Dentistry | 12 | 22% |
Chemistry | 6 | 11% |
Biochemistry, Genetics and Molecular Biology | 5 | 9% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 5% |
Other | 4 | 7% |
Unknown | 10 | 18% |