One of the main clinical features characterizing crystal-induced inflammation is its spontaneous resolution. The aim of this review is to outline the various factors involved in the self-limiting course of crystal-induced inflammation focusing on their effect on IL-1β production. Endogenous molecules that are induced or locally recruited by the process itself, inhibitory proteins naturally present in the joint and exogenous dietary factors are discussed. Aside from the classical well-known molecules involved in the resolution of crystal-induced acute attack such as TGFβ, IL-10, IL-1Ra, and lipoproteins, particular attention is paid to recently uncovered mechanisms such as the aggregation of neutrophil extracellular traps, the release of ectosomes from neutrophil surface, and alpha-1-anti-trypsin-mediated IL-1 inhibition.
Pharmacology, Toxicology and Pharmaceutical Science
2
13%
Biochemistry, Genetics and Molecular Biology
1
7%
Linguistics
1
7%
Business, Management and Accounting
1
7%
Other
2
13%
Unknown
3
20%
Attention Score in Context
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 March 2017.
All research outputs
#20,411,380
of 22,961,203 outputs
Outputs from Frontiers in Pharmacology
#10,144
of 16,230 outputs
Outputs of similar age
#268,927
of 308,511 outputs
Outputs of similar age from Frontiers in Pharmacology
#128
of 201 outputs
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