Title |
Fatal Outcome of European Tick-borne Encephalitis after Vaccine Failure
|
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Published in |
Frontiers in Neurology, April 2017
|
DOI | 10.3389/fneur.2017.00119 |
Pubmed ID | |
Authors |
Parham Sendi, Cédric Hirzel, Stefan Pfister, Rahel Ackermann-Gäumann, Denis Grandgirard, Ekkehard Hewer, Arto C. Nirkko |
Abstract |
Tick-borne encephalitis is a viral disease affecting the central nervous system. It is endemic in Switzerland with 200-250 notified cases annually. Active immunization is effective for persons in all age groups. Vaccine failure is rare, in particular after a completed vaccination course. Here, we describe the case of 67-year-old man with a fatal outcome despite vaccination. The diagnosis was confirmed by extensive postmortem analyses. The diagnostic challenges of vaccine failure in tick-borne encephalitis and the dynamics of the immune response in vaccination breakthrough are discussed. |
X Demographics
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Geographical breakdown
Country | Count | As % |
---|---|---|
Norway | 1 | 20% |
Switzerland | 1 | 20% |
Unknown | 3 | 60% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 5 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 37 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 13 | 35% |
Researcher | 6 | 16% |
Student > Doctoral Student | 4 | 11% |
Other | 4 | 11% |
Student > Master | 2 | 5% |
Other | 3 | 8% |
Unknown | 5 | 14% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 13 | 35% |
Immunology and Microbiology | 12 | 32% |
Veterinary Science and Veterinary Medicine | 2 | 5% |
Arts and Humanities | 2 | 5% |
Biochemistry, Genetics and Molecular Biology | 1 | 3% |
Other | 1 | 3% |
Unknown | 6 | 16% |