Title |
Cigarette smoke induces endoplasmic reticulum stress and the unfolded protein response in normal and malignant human lung cells
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Published in |
BMC Cancer, August 2008
|
DOI | 10.1186/1471-2407-8-229 |
Pubmed ID | |
Authors |
Ellen Jorgensen, Andy Stinson, Lin Shan, Jin Yang, Diana Gietl, Anthony P Albino |
Abstract |
Although lung cancer is among the few malignancies for which we know the primary etiological agent (i.e., cigarette smoke), a precise understanding of the temporal sequence of events that drive tumor progression remains elusive. In addition to finding that cigarette smoke (CS) impacts the functioning of key pathways with significant roles in redox homeostasis, xenobiotic detoxification, cell cycle control, and endoplasmic reticulum (ER) functioning, our data highlighted a defensive role for the unfolded protein response (UPR) program. The UPR promotes cell survival by reducing the accumulation of aberrantly folded proteins through translation arrest, production of chaperone proteins, and increased degradation. Importance of the UPR in maintaining tissue health is evidenced by the fact that a chronic increase in defective protein structures plays a pathogenic role in diabetes, cardiovascular disease, Alzheimer's and Parkinson's syndromes, and cancer. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
India | 1 | <1% |
Czechia | 1 | <1% |
United Kingdom | 1 | <1% |
Mexico | 1 | <1% |
Japan | 1 | <1% |
United States | 1 | <1% |
Unknown | 118 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 25 | 20% |
Student > Ph. D. Student | 23 | 19% |
Student > Bachelor | 15 | 12% |
Student > Master | 9 | 7% |
Student > Doctoral Student | 8 | 6% |
Other | 24 | 19% |
Unknown | 20 | 16% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 26 | 21% |
Agricultural and Biological Sciences | 25 | 20% |
Biochemistry, Genetics and Molecular Biology | 21 | 17% |
Nursing and Health Professions | 6 | 5% |
Pharmacology, Toxicology and Pharmaceutical Science | 6 | 5% |
Other | 16 | 13% |
Unknown | 24 | 19% |