Title |
Novel Triazole linked 2-phenyl benzoxazole derivatives induce apoptosis by inhibiting miR-2, miR-13 and miR-14 function in Drosophila melanogaster
|
---|---|
Published in |
Apoptosis, April 2017
|
DOI | 10.1007/s10495-017-1367-1 |
Pubmed ID | |
Authors |
Tanmoy Mondal, A. V. S. Lavanya, Akash Mallick, Tulshiram L. Dadmala, Ravindra M. Kumbhare, Utpal Bhadra, Manika Pal Bhadra |
Abstract |
Apoptosis is an important phenomenon in multi cellular organisms for maintaining tissue homeostasis and embryonic development. Defect in apoptosis leads to a number of disorders like- autoimmune disorder, immunodeficiency and cancer. 21-22 nucleotides containing micro RNAs (miRNAs/miRs) function as a crucial regulator of apoptosis alike other cellular pathways. Recently, small molecules have been identified as a potent inducer of apoptosis. In this study, we have identified novel Triazole linked 2-phenyl benzoxazole derivatives (13j and 13h) as a negative regulator of apoptosis inhibiting micro RNAs (miR-2, miR-13 and miR-14) in a well established in vivo model Drosophila melanogaster where the process of apoptosis is very similar to human apoptosis. These compounds inhibit miR-2, miR-13 and miR-14 activity at their target sites, which induce an increased caspase activity, and in turn influence the caspase dependent apoptotic pathway. These two compounds also increase the mitochondrial reactive oxygen species (ROS) level to trigger apoptotic cell death. |
X Demographics
As of 1 July 2024, you may notice a temporary increase in the numbers of X profiles with Unknown location. Click here to learn more.
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 9 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 3 | 33% |
Researcher | 2 | 22% |
Student > Bachelor | 1 | 11% |
Lecturer > Senior Lecturer | 1 | 11% |
Student > Master | 1 | 11% |
Other | 1 | 11% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 3 | 33% |
Biochemistry, Genetics and Molecular Biology | 2 | 22% |
Chemistry | 1 | 11% |
Unknown | 3 | 33% |