Title |
Prevalence and molecular basis of glucose-6-phosphate dehydrogenase deficiency in Afghan populations: implications for treatment policy in the region
|
---|---|
Published in |
Malaria Journal, July 2013
|
DOI | 10.1186/1475-2875-12-230 |
Pubmed ID | |
Authors |
Toby Leslie, Bushra Moiz, Nader Mohammad, Omar Amanzai, Haroon ur Rasheed, Sakhi Jan, Abdul M Siddiqi, Amna Nasir, Mohammad A Beg, Martijn Vink |
Abstract |
Glucose-6-phosphate dehydrogenase deficiency (G6PD), an x-linked inherited enzymopathy, is a barrier to malaria control because primaquine cannot be readily applied for radical cure in individuals with the condition. In endemic areas, including in Afghanistan, the G6PD status of vivax patients is not routinely determined so the drug is rarely, if ever, prescribed even though it is included as a recommended treatment in local, regional and global guidelines. This study assessed the prevalence and genotype of G6PD deficiency in Afghan populations and examined the need for routine G6PD testing as a malaria treatment and control tool. |
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Mendeley readers
Geographical breakdown
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