Title |
Spirochetal Lipoproteins and Immune Evasion
|
---|---|
Published in |
Frontiers in immunology, March 2017
|
DOI | 10.3389/fimmu.2017.00364 |
Pubmed ID | |
Authors |
Alexei Christodoulides, Ani Boyadjian, Theodoros Kelesidis |
Abstract |
Spirochetes are a major threat to public health. However, the exact pathogenesis of spirochetal diseases remains unclear. Spirochetes express lipoproteins that often determine the cross talk between the host and spirochetes. Lipoproteins are pro-inflammatory, modulatory of immune responses, and enable the spirochetes to evade the immune system. In this article, we review the modulatory effects of spirochetal lipoproteins related to immune evasion. Understanding lipoprotein-induced immunomodulation will aid in elucidating innate pathogenesis processes and subsequent adaptive mechanisms potentially relevant to spirochetal disease vaccine development and treatment. |
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