Title |
The potential roles of T-type Ca2+ channels in motor coordination
|
---|---|
Published in |
Frontiers in Neural Circuits, January 2013
|
DOI | 10.3389/fncir.2013.00172 |
Pubmed ID | |
Authors |
Young-Gyun Park, Jeongjin Kim, Daesoo Kim |
Abstract |
Specific behavioral patterns are expressed by complex combinations of muscle coordination. Tremors are simple behavioral patterns and are the focus of studies investigating motor coordination mechanisms in the brain. T-type Ca(2+) channels mediate intrinsic neuronal oscillations and rhythmic burst spiking, and facilitate the generation of tremor rhythms in motor circuits. Despite substantial evidence that T-type Ca(2+) channels mediate pathological tremors, their roles in physiological motor coordination and behavior remain unknown. Here, we review recent progress in understanding the roles that T-type Ca(2+) channels play under pathological conditions, and discuss the potential relevance of these channels in mediating physiological motor coordination. |
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