Title |
Current Understanding of the Pathophysiology of Myocardial Fibrosis and Its Quantitative Assessment in Heart Failure
|
---|---|
Published in |
Frontiers in Physiology, April 2017
|
DOI | 10.3389/fphys.2017.00238 |
Pubmed ID | |
Authors |
Tong Liu, Deli Song, Jianzeng Dong, Pinghui Zhu, Jie Liu, Wei Liu, Xiaohai Ma, Lei Zhao, Shukuan Ling |
Abstract |
Myocardial fibrosis is an important part of cardiac remodeling that leads to heart failure and death. Myocardial fibrosis results from increased myofibroblast activity and excessive extracellular matrix deposition. Various cells and molecules are involved in this process, providing targets for potential drug therapies. Currently, the main detection methods of myocardial fibrosis rely on serum markers, cardiac magnetic resonance imaging, and endomyocardial biopsy. This review summarizes our current knowledge regarding the pathophysiology, quantitative assessment, and novel therapeutic strategies of myocardial fibrosis. |
X Demographics
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Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Science communicators (journalists, bloggers, editors) | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 322 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 58 | 18% |
Student > Bachelor | 46 | 14% |
Student > Master | 36 | 11% |
Researcher | 21 | 7% |
Student > Doctoral Student | 17 | 5% |
Other | 51 | 16% |
Unknown | 93 | 29% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 83 | 26% |
Biochemistry, Genetics and Molecular Biology | 46 | 14% |
Engineering | 20 | 6% |
Agricultural and Biological Sciences | 14 | 4% |
Pharmacology, Toxicology and Pharmaceutical Science | 14 | 4% |
Other | 34 | 11% |
Unknown | 111 | 34% |