Ankit Saxena, Hideo Yagita, Thomas W. Donner, Abdel Rahim A. Hamad
Abstract
Fas ligand drives insulitis in the non-obese diabetic mouse model of type 1 diabetes (T1D) and negatively regulates IL-10-producing (IL-10(pos)) CD5(+) B cells in pancreata. Relevance of these phenomena to the human disease is poorly understood. Here, using splenocytes from T1D, autoantibody (Ab(+)), and non-diabetic (ND) human subjects, we show that a subpopulation of CD5(+) B cells that is characterized by expression of FasL (FasL(hi)CD5(+)) was significantly elevated in T1D subjects, many of whom had significantly reduced frequency of IL-10(pos)CD5(+) B cells compared to Ab(+) subjects. The majority of FasL(hi)CD5(+) B cells did not produce cytokines and were more highly resistant to activation-induced cell death than their IL-10(pos)CD5(+) counterparts. These results associate expansion of FasL-expressing CD5(+) B cells with T1D and lay the groundwork for future mechanistic studies to understand specific role in disease pathogenesis.
This research output has an Altmetric Attention Score of 25. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 May 2019.
All research outputs
#1,537,957
of 25,382,440 outputs
Outputs from Frontiers in immunology
#1,367
of 31,531 outputs
Outputs of similar age
#29,794
of 324,698 outputs
Outputs of similar age from Frontiers in immunology
#23
of 414 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 31,531 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 324,698 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 90% of its contemporaries.
We're also able to compare this research output to 414 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.
