Title |
Using Murine Models to Investigate Tumor–Lymphoid Interactions: Spotlight on Chronic Lymphocytic Leukemia and Angioimmunoblastic T-Cell Lymphoma
|
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Published in |
Frontiers in oncology, May 2017
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DOI | 10.3389/fonc.2017.00086 |
Pubmed ID | |
Authors |
Tyler A. Herek, Christine E. Cutucache |
Abstract |
The role of the tumor microenvironment in leukemias and lymphomas is well established, yet the intricacies of how the malignant cells regulate and influence their non-malignant counterparts remain elusive. For example, chronic lymphocytic leukemia (CLL) is an expansion of malignant CD5(+)CD19(+) B cells, yet the non-malignant T cells play just as large of a role in disease presentation and etiology. Herein, we review the dynamic tumor cell to lymphoid repertoire interactions found in two non-Hodgkin's lymphoma subtypes: CLL and angioimmunoblastic T-cell lymphoma. We aim to highlight the pivot work done in the murine models which recapitulate these diseases and explore the insights that can be gained from studying the immuno-oncological regulation of non-malignant lymphoid counterparts. |
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Switzerland | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
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Unknown | 14 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 6 | 43% |
Student > Doctoral Student | 2 | 14% |
Student > Bachelor | 2 | 14% |
Other | 1 | 7% |
Student > Master | 1 | 7% |
Other | 1 | 7% |
Unknown | 1 | 7% |
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Immunology and Microbiology | 5 | 36% |
Biochemistry, Genetics and Molecular Biology | 3 | 21% |
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Medicine and Dentistry | 1 | 7% |
Other | 1 | 7% |
Unknown | 2 | 14% |